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KMID : 0369319950150020223
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Allergy
1995 Volume.15 No. 2 p.223 ~ p.229
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Airway responsiveness in patients with chronic cough
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최승원
유빈/문희범
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Abstract
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Chronic cough is one of the most cornmon respiratory symptorns and can be the sole presenting manifestation of bronchial asthma. Sornetimes it is difficult to find out the etiology because of its heterogenous pathogenesis. We investigated the prevalence of airway hyperresponsiveness and their relation to clinical or laboratory features in patients with chronic cough.
We studied 59 individuals over the age 16, who had presented with cough of more than 8 weeks duration without history of dyspnea or wheezing. Methacholine bronchial challenge tests were done at concentrations of 0.625 25mg/ml, and positive response was defined as a reduct,ion in FEV, by 20% or more.
Results were as follows.
1) Forty two percent of patients showed positive responses to methacholine challenge and 32% of patients developed cough during challenge test without expiratory flow lirnitation.
2) The results of bronchial provocation test were not related to patients age, basal lung functions, recurrency of cough, presence of postnasal drip syndrome or atopy.
These results indicated that airway responsiveness is not predictable on the basis of clinical features or ordinary laboratory findings in patients with chronic cough and that non-specific bronchial provocationtest is mandatory in evaluating these patients. Also suggested was the existence of the cough type bronchial responsiveness which could be separated from the constriction type response.
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